Eric Nestler Quotes

Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond appropriately. - Eric Nestler

The social-defeat process induced production of BDNF in the reward circuit. Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond accordingly. - Eric Nestler

The molecular scar induced by chronic stress in the hippocampus, and perhaps elsewhere in the brain, can't be easily reversed. To really cure depression, we probably need to find new treatments that can remove the silencer molecules. - Eric Nestler

The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically. The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues. - Eric Nestler

That would make addiction more inheritable than diseases we commonly think of as genetic, such as adult onset diabetes or common hypertension. - Eric Nestler

Removal of BDNF before bullying, or treatment with antidepressants after bullying, both removed the behavioral abnormality observed. - Eric Nestler

Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants. - Eric Nestler

Maybe there's a faster or better way to treat depression if you approach the problem from two different directions. - Eric Nestler

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