Eric Nestler Quotes

The molecular scar induced by chronic stress in the hippocampus, and perhaps elsewhere in the brain, can't be easily reversed. To really cure depression, we probably need to find new treatments that can remove the silencer molecules.

- Eric Nestler

Tags

Molecular | Scar | Induced | Chronic | Stress |

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The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically. The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues. - Eric Nestler

That would make addiction more inheritable than diseases we commonly think of as genetic, such as adult onset diabetes or common hypertension. - Eric Nestler

The social-defeat process induced production of BDNF in the reward circuit. Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond accordingly. - Eric Nestler